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n-nitroso-n-methylurea carcinogen mutagen teratogen alkylating agent toxicity methyl group nucleobases nucleic acids transition mutations synthesis diazomethane fetal resorption craniofacial cleft palate embryotoxic carcinoma sarcoma glioma adenocarcinoma leukemia lymphoma rendering toxicant toxic toxin toxicology danger hazard acute harmful exposure antidote intoxication detoxification mutagenic mutagenesis genotoxic cancer carcinogenicity carcinogenic tumor promotion malignancy angiogenesis