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compound molecular formula 3-hydroxyanthranilic acid tryptophan antioxidant 2-amino-3-hydroxybenzoic tempeh kynurenine pathway quinolinic kynurenic hydroxy anthranilic dioxygenase chemical substance picolinic hana hydroxybenzoic nicotinic kmo kegg hmdb yeast treatment molar mass solubility 3d rendering molecule structural structure production metabolite metabolism biosynthesis cycle mechanism path catabolism biosynthetic intermediate biogenesis precursor synthesis derivative