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ractopamine feed additive leanness farmed animals banned phenol-based taar1 agonist adrenoreceptor meat production ractopamine hydrochloride stereoisomer positional isomer dobutamine food muscle tissues murine beta-adrenergic receptor protein synthesis food-producing acute toxicity livestock 3d side effect adverse action iatrogenic overdose contraindications interaction pharmacodynamics pharmacokinetics poison venom toxicant toxic toxin toxicology poisoning danger hazard harmful kill exposure limit intoxication detoxification bane