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chemical receptor triiodothyronamine thyronamine diiodotyrosine thyroid hormone everted iodophenol cell lysate hep g2 substrates trace amine cardiac function action t0am thyroxine t4 t3 taar1 tar1 t2am t3am t1am iodine 3d rendering molecule molecular structural structure formula compound derivative hormonal therapy replacement metabolite metabolism biosynthesis cycle mechanism pathway path biosynthetic