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cholecystokinin cck cck-pz peptide hormone gastrointestinal digestion fat protein pancreozymin enteroendocrine cells duodenum small intestine digestive enzymes pancreas gallbladder hunger suppressant anorectic anorexic appetite appetite anorexigenic anorexiant panicogenic anxiogenic hallucinogenic visual hallucinations parkinson's disease 3d enzyme metabolic precursor action bioprecursor path biosynthesis catabolism pathway prohormone therapy substrate biogenesis derivative synthesis hmdb contractor analogue endocrine