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synthesis reaction isomer isomeric aminonaphthalenes azo dyes cigarette smoke 2-naphthylamine naphthylamine naphthalen-2-amine hydroxy naphthalene phenylacetate addition coupling organolithium salt preparation malignancy bladder glucuronic 3d rendering chemical organic molecule molecular structural structure formula agent compound reagent production iupac aromatic toxicity toxin danger hazard harmful carcinogen cancer carcinogenicity carcinogenic tumor promotion