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saccharin sodium ?954 saccharin sodium salt phenolphthalein sweet saccharine anhydrous saccharinate cristallose sucromat crystallose kristallose willosetten madhurin soluble saccharide artificial sweetener food additive adjuvants ingredient agent ins number aftertaste drinks candies cookies bitter medicines ortho-benzoic sulfimide ortho sulphobenzamide heat-stable carbonated soft safety bladder cancer carcinogen carcinogenicity carcinogenic carcinogenesis molecule molecular formula skeletal structural structure 3d