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polysorbate 80 synthetic nonionic surfactant chemotherapy supportive care ingredients vitamin-mineral carcinogenic contaminant carcinogen emulsifier polyethoxylated sorbitan oleic acid polyoxyethylene sorbitan monooleate hydrophilic number e433 critical micelle concentration food additive adjuvants emulsify agent ins solubilizer 3d cleansing hydrophobic detergent zwitterionic surface tension micelle surfaces emulsifying substance matter material compound component functional group precursor synthesis reaction production building block