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ouabain arrow poison g-strophanthin cardiac glycoside venom toxicant toxic toxicity toxin toxicology poisoning danger hazard acute harmful kill exposure limit antidote intoxication detoxification phytotoxin hypotension herbal phytochemical phytotherapy plant herb natural herbalism pharmacognosy pharmacopoeia arrhythmias sodium-potassium ion pump extremely hazardous substance acokanthera schimperi strophanthus gratus schimperi sodium-calcium exchanger african crested rat 3d molecule molecular formula skeletal structural structure geometry