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maleic acid cis-butenedioic malenic maleinic toxilic but-2-enedioic heat combustion intramolecular hydrogen bonding glyoxylic ozonolysis fumaric isomerization photolysis maleate isomerase biochemistry transaminase reaction carfenazine chlorpheniramine pyrilamine methylergonovine thiethylperazine substance matter material compound component agent stuff reagent functional group precursor synthesis production building block cell biology biochemistry biomolecule bioactive 3d molecule molecular formula skeletal structural structure geometry organic