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lomustine ccnu alkylating nitrosourea compound semustine streptozotocin blood-brain barrier brain tumors hodgkin lymphoma white blood cells alkylating agent dna rna cell-cycle nonspecific mast cell tumor nonspecific antineoplastic agents ccns cycle anthracyclins rendering chemotherapy chemotherapy regimen antineoplastic chemo ctx cancer treatment anti-cancer anticancer anti-tumor oncology mitosis inhibit cytotoxic immunosuppression myelosuppression targeted therapies topoisomerase antimetabolite emetogenic chemotherapy-induced nausea vomiting cinv side effect mechanism action pharmacodynamics pharmacokinetics