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estradiol dienantate ede estrogen estrogen ester eden e2-edn diheptanoate estradiol long-acting medication menopausal hormone therapy women suppress lactation combination eb tebh injection breast tenderness enlargement nausea headache fluid retention agonist receptor prodrug breastfeeding 3d function hormonal birth control gynecological conditions birth hormonal endocrine action female reproductive analogue motherhood replacement level mother reproduction gynecology prohormone woman