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chlorophenol organochloride phenol electrophilic halogenation chlorine 3d pesticides toxicity persistent organic pollutants compound aromatic efsa anthropogenic hera reaction toxicology banned building detoxification bane organic harmful environment damage non-biodegradable exposure intoxication msds functional cecs material biodegradation naaqs danger production poisoning aromaticity toxicant pollution component lc50 irritant ntp bioaccumulating matter acute