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4-aminobiphenyl 4-apb 4-phenylaniline aminodiphenyl xenylamine msds amine urine sample linearity domain structure bladder cancer hydroxy cas phenyl group adducts hplc aromatic chemical aminobiphenyl figura tobacco smoke synthesis metabolism biphenyl dyes dna aryl-amine 3d rendering molecule molecular structural formula toxic toxicity hazard ld50 carcinogen carcinogenicity carcinogenic tumor promotion malignancy angiogenesis