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kidney damage adenine phosphoribosyltransferase deficiency xanthine cystine struvite calcium phosphate supersaturation hypercalcemia crystalluria randall plaque electrolytes uric acid renal papilla nucleation seed crystal oxalate blood cells colic ureter kidneys stones urinary tract crystallopathy urolithiasis kidney diagram anatomical healthy urinary disease isolated system organ vector biology medicine health science body medical anatomy human nephrolithiasis