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Siena or Siena (ital. Siena [ˈsjÉ›Ëna]) is a city in the Italian region of Tuscany, the administrative center of the homonymous province, one of the largest tourist centers of Italy. In the Middle ages the capital of the powerful Republic of Siena, the center of artistic life in the epoch of the trecento. The well-preserved medieval core of Siena is under UNESCO protection as a world heritage site.