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skin anatomy sensory receptors cross hydration rejuvenation dry acne nerve cutaway medical layer epidermis dermis adiose tissue subcataneous stratum basale blood vessels meissner 039 corpuscle pacinian hair shaft follicle sweat pore horny adipose sebaceous gland arrector pili muscle root plexus endings healthcare biology dermatology dermatologist aging age colour science scientific black artwork labeled concept anatomy receptors showing nerves fat cells