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mobile microglial cell type neuroglia microglia immune cells found central nervous system cns mammals including humans resident macrophages play crucial role maintaining brain homeostasis responding injury infection primary defense engulfing clearing cellular debris pathogens abnormal proteins process phagocytosis participate neuroinflammation contribute synaptic pruning development additionally implicated neurological disorders alzheimer's disease parkinson's multiple sclerosis cell microglia neuroglia glial system tissue anatomy animal biology brain structure human design histology isolated macrophage medicine morphology neuroscience processes science spinal cord