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viral warts hypersegmented neutrophil hypogammaglobulinemia rare autosomal dominant genetic low red blood cells pattern inheritance primary immunodeficiency myelokathexis neutropenia congenital chronic noncyclic molecular biology immunology aberrant chemokine receptor white cell targeted therapy chromothripsis bacterial infections plerixafor cxcr4 antagonist stem shrinkage immune globulins mavorixafor signaling system hematology oncology non-hodgkin lymphoma hands feet residues truncation downregulation