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The ABO blood group system is used to denote the presence of one, both, or neither of the A and B antigens on erythrocytes. The ABO gene encodes a glycosyltransferase that catalyzes the transfer of carbohydrates to the H antigen, forming the antigenic structures of the ABO blood group. The proteins encoded by the A and B alleles of ABO differ minimally in amino acid sequence but catalyze the transfer of different carbohydrates onto the H antigen to form the A or B antigens. Individuals with the O blood group do not produce either the A or B antigens.