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colistin polymyxin antibiotic molecule molecular structure gramnegative infections antibiotics cyclic peptides polypeptide formaldehyde chemical formula model c52h98n16o13 atom chemistry resistance kidney atomic membrane detergent antibacterial composition disruption drawing skeletal flat compound icon colistine mcr1 nephrotoxicity polymyxa drug medicine colistimethate paenibacillus pharmaceutical treatment colobreathe colymycin xylistin sodium bisulfite structural view from microscope