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body central charcot-marie-tooth disease contraction design devic foot genetic guillain-barr syndrome human idiopathic illustration inflammatory isolated leg leukodystrophy leukoencephalopathy model motor movement multiple sclerosis muscle myelin myelinoclastic nervous neuromyelitis optica neuronal neuropathy sheath spinal syphilis syphilitic myelopathy system tabes dorsalis vitamin b12 deficiency