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butylated hydroxytoluene c15h24o lipophilic organic compound dibutylhydroxytoluene bht food additive synthetic antioxidant preservative e321 chemical white crystalline powder antioxidant activity lipid oxidation radicals stabilizer cosmetic industry pharmaceutical plastic rubber animal feed maximum permitted level safety concerns side effects toxicity carcinogenicity endocrine disruptor genotoxicity mutagenicity environmental impact conformer additives background chemistry clipping mask element flavor food health ingredient isolated mask channel modification molecular molecule preservatives structure transparent layer