Chinese Betel Leaves (Peperomia pellucida L.) can be an alternative drug for breast cancer therapy. Based on research conducted jointly in medicine, it was found that the apoptogenic activity of Chinese betel leaf extract was tested in vitro with a cell viability test using tryphan blue and an immunofluorescence test to see the expression of Caspase-3, and an in silico test using the LCMS test to determine the various bioactive components in it.