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man endemic goiter toxic thyroid gland histology endocrine receptor autoimmune endocrinology hyperthyroidism histopathology graves autoantibodies autoantigens autoimmunity colloid dysfunction enlargement follicular histopathological hormones antibodies function 3d illustration anatomical immune scientific disease medical disorder pathology thyrotoxicosis thyroiditis cellular male mature adult one person exophthalmos eyes caucasian european middle age senior 50s white background