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rendering synapse deconstruction alzheimers disease showing cognitive decline neurological damage alzheimer 039 brain deterioration neurodegeneration memory loss protein aggregation amyloid plaques tau tangles synaptic dysfunction neuronal death neuroinflammation betaamyloid accumulation pruning neurotransmitter imbalance plasticity impairment dendritic spine atrophy neural network disruption transmission neurofibrillary degeneration axonal cell neurocognitive neuroimaging aigenerated