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toluenesulfonic acid p-toluenesulfonic 4-methylbenzene-1-sulfonic 4-methylbenzenesulfonic tosylic tosic ptsa ptsoh tsoh tosyl group sulfonic strong organic fischer–speier esterification transesterification reaction acetalization aldehyde tosylates alkylating agents electron-withdrawing hydrolysis substance matter material compound component agent stuff reagent functional precursor synthesis production building block molecule molecular formula skeletal structural structure 3d chemistry science scientific research organic chemical tautomer isomer