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oxprenoate potassium synthetic steroidal antimineralocorticoid ru-28318 affinities steroid hormone receptors mineralocorticoid receptor antagonist mcra aldosterone diuretic drug antagonizes aldosterone chronic heart failure hyperaldosteronism conn's syndrome rendering hormone hormonal therapy replacement function action endocrine endocrinology level prohormone analogue mineralocorticoid corticosteroid glucocorticosteroid glucocorticoid receptor inflammation immune system autoimmune disease stress response carbohydrate metabolism protein catabolism anti-inflammatory