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ochratoxin ethyl ester analog food contaminant aspergillus penicillium toxin mycotoxin food-contaminating carcinogenicity carcinogenic mutagenic hepatocellular carcinomas carcinoma neurotoxicity brain immunosuppression immunotoxicity rendering poison venom toxicant toxic toxicity poisoning danger hazard msds ntp ld50 irritant acute efsa lc50 harmful kill exposure antidote intoxication detoxification carcinogen cancer tumor promotion malignancy angiogenesis