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norabietane diterpene perhydrogenated phenanthrene derivative fichtelite isoprene antimicrobial antiinflammatory biosynthesis cytochromes p450 diterpenoid 3d supplement biological activity bioactive nutrient prescription drug food additive nutraceutica dietary antioxidant anti-cancer anti-aging healthy aging alternative medicine tcm traditional chinese herbal herbal phytochemical phytotherapy plant herb natural herbalism pharmacognosy pharmacopoeia parasympathomimetic flavonoid phytoestrogen molecule molecular formula skeletal structural structure geometry ball stick