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nisterime synthetic anabolic-androgenic steroid aas derivative dihydrotestosterone dht acetate ester nisterime acetate orf-9326 postcoital contraceptive rendering contraception birth control hormonal oral contraceptives hormone hormonal therapy replacement function action endocrine endocrinology level prohormone analogue anabolic androgenic androgen male sex masculinizing steroidal anabolism appetite puberty body weight masculinization irreversible performance-enhancing drug medication side effect adverse iatrogenic overdose contraindications