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monosialotetrahexosylganglioside gm1 ganglioside sialic acid neuronal plasticity neurotrophins brain coli heat-labile enterotoxin cholera toxin inherited disease guillain–barre syndrome dementia lupus diarrhea multifocal motor neuropathy mmn antibody-mediated inflammatory vibrio cholerae neurodegenerative condition substantia nigra parkinson's spinal cord injury apoptosis necrosis neurodegeneration amyotrophic lateral sclerosis multiple alzheimer's huntington's system atrophy prion diseases cell death 3d phosphatidylcholine pc lecithin sphingomyelin phosphatidylethanolamine phospholipid membrane cholesterol lysophosphatidylcholine bilayer glycerophospholipid phosphatidylserine lipophilic