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lactitol ?966 food additive adjuvants ingredient agent ins number sugar alcohol sweetener sucrose laxative food energy low fat baking sugar-free candies cookies biscuits chocolate ice cream colon prebiotic kilocalories saccharide excipient constipation chronic idiopathic cic ispaghula generally recognized safe gras blood glucose cramping flatulence diarrhea suitable beta-galactosidase gastrointestinal tract large intestine gut microbes 3d molecule molecular formula skeletal structural structure ball stick