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imipenem intravenous beta-lactam antibiotic carbapenem streptomyces cattleya bacteria flora resistance bacterial antimicrobial bactericide pathogen gram-positive gram-negative antibiotic-resistant antibacterial agent infections microorganism strain antimicrobial chemotherapy aerobic anaerobic pseudomonas aeruginosa enterococcus mrsa acinetobacter aeromonas bacteroides clostridium drug preparation mount treatment medicine medicament remedy cure medication side effect adverse action iatrogenic overdose contraindications interaction 3d