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guibourtinidol flavan-3ol cassia abbreviata heartwood flavanol flavonoid flavan catechin epicatechin gallate epigallocatechin epigallocatechin proanthocyanidins theaflavins thearubigins proanthocyanidin rendering supplement biological activity bioactive nutrient prescription drug food additive nutraceutica dietary vitamin antioxidant anti-cancer anti-aging healthy aging alternative medicine tcm traditional chinese herbal herbal phytochemical phytotherapy plant herb natural herbalism pharmacognosy pharmacopoeia cell biochemistry biology biomolecule