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farnesyl pyrophosphate fpp diphosphate fdp intermediate biosynthesis terpenes terpenoid sterol carotenoid coq synthase prenyl transferase geranyl pyrophosphate bisphosphonates osteoporosis rendering supplement biological activity bioactive nutrient prescription drug food additive nutraceutica dietary vitamin antioxidant anti-cancer anti-aging healthy aging alternative medicine tcm traditional chinese herbal herbal phytochemical phytotherapy plant herb natural herbalism pharmacognosy pharmacopoeia parasympathomimetic alkaloid flavonoid phytoalexin