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polysorbate 60 emulsifier food preparation additive essential oils ethoxylated sorbitan sorbitol fatty acids flammable cancer toxicity cosmetic ingredients emulsifying carcinogenicity skin allergies developmental reproductive synthetic ingredient skincare surfactant 3d substance matter material compound component agent functional group precursor synthesis reaction production building block cleansing hydrophilic hydrophobic synthetic detergent zwitterionic surface tension micelle surfaces food adjuvants