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enzacamene 4-methylbenzylidene camphor 4-mbc camphor derivative organic cosmetic skin uv sunscreen lotions skincare spf photon energy cis-trans isomerisation photochemical endocrine disruptor estrogenic hypothyroidism rendering substance matter material compound component agent stuff reagent functional group precursor synthesis reaction production building block atom molecule molecular structural structure formula skeletal geometry ball stick tautomer isomer stereoisomer orbital structure activity relationship