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dodecyldimethylamine oxide ddao organosulfur compound sulfoxide methanesulfinyl methane methylsulfinylmethane methyl dermasorb dimethyloxidosulfur polar aprotic solvent polar nonpolar trigonal pyramidal molecular geometry acidity oxidant organic synthesis pfitzner–moffatt oxidation corey–kim swern kornblum ligand lewis base coordination chemistry biology polymerase chain reaction pcr dna cryoprotectant medicine veterinary alternative molecule molecular structural structure formula 3d substance component agent reagent precursor production