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dehydroepiandrosterone dhea androstenolone endogenous steroid hormone precursor androgen estrogen sex biosynthesis tissues neurotrophic factor receptors adrenarche body odor acne complete androgen insensitivity syndrome cais hair follicles hair pubarche neurosteroid neurotrophin central nervous system neurotransmitter hormonal therapy replacement function action endocrine endocrinology level prohormone analogue g6pdh inhibitor adhd microtubule-associated protein antiinflammatory antihyperplastic chemopreventative antihyperlipidemic antidiabetic antiobesic immunomodulating 3d molecule molecular