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curare alkaloid arrow poison paralyzing agent therapeutic hunting arrow dart venom toxicant toxic toxicity toxin toxicology poisoning danger hazard acute harmful kill exposure limit antidote intoxication detoxification nicotinic acetylcholine receptor nachr neuromuscular junction skeletal muscles asphyxiation paralysis diaphragm tetanus strychnine surgical procedures chondrodendron tomentosum strychnos toxifera pancuronium curare-like transmission 3d molecule molecular formula skeletal structural structure geometry