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clofibric acid clofibrin chlorophenoxyisobutyric biologically active metabolite clofibrate etofibrate theofibrate drug lipid-lowering environment derivative fibrates metabolism biosynthesis cycle mechanism pathway path catabolism biosynthetic intermediate biogenesis substrate precursor synthesis bioprecursor metabolic enzyme endogenous contractor medication side effect adverse action iatrogenic overdose contraindications interaction pharmacology pharmaceutics pharmaceutical pharmacy pharma pharmacodynamics pharmacokinetics 3d