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guanitoxin anatoxin-a gnt salivary cyanotoxin cyanobacteria anabaena acetylcholinesterase organophosphate toxicity acetylcholine parasympathetic peripheral nervous systems salivation lacrimation chromodacryorrhea urinary incontinence muscular weakness muscle twitching convulsion including opisthotonus respiratory distress poison venom toxicant toxic toxin toxicology poisoning danger hazard msds ntp ld50 irritant acute efsa lc50 harmful kill exposure limit antidote intoxication detoxification banned bane 3d